Antibacterial effect of chitosan nanoparticle in root canal disinfection

Comparison Of Antimicrobial Efficacy Of Chlorhexidine Combined With Nano Chitosan And Chitosan Particle As Root Canal Irrigants In Apical Periodontitis - A Randomized Clinical Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/04/042189

Enrollment

Registered

2022-04-27

Start date

Unknown

Completion date

Unknown

Last updated

2023-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Chitosan nanoparticles with chlorhexdine: Chitosan nanoparticles with 2% chlorhexdine Duration of therapy- 60 mins Control Intervention1: Sodium Hypochlorite: 3% Sodium Hypochlorite

Eligibility

Inclusion criteria

Inclusion criteria: 1.Teeth with apical periodontitis. 2.Permanent teeth with fully formed apex 3. Teeth with straight root canals 4. Teeth with single canal

Exclusion criteria

Exclusion criteria: 1.Permanent teeth with open apex. 2. Permanent teeth with more than one root canal. 3.Patients having systemic complications

Design outcomes

Primary

Measure	Time frame
Antibacterial efficacy using Rt PCR S1- Pre irrigation S2- Post irrigationTimepoint: S1- Baseline S2- 30 mins	—

Secondary

Measure	Time frame
Post operative pain level using a numeric rating scaleTimepoint: 0hrs,6hrs,24hrs,72hrs,168hrs	—

Countries

India

Contacts

Public ContactDr Sindhu Ramesh

Saveetha Dental College and Hospitals

sindhuramesh@saveetha.com9840136543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026