Health Condition 1: C719- Malignant neoplasm of brain, unspecified
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
Dr Navneet Singla
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients newly diagnosed with high grade glioma and having indication for surgery. 2. Adult (more than 18 years) patients of either sex. 3. Patients having given informed and written consent for participation in the study.
Exclusion criteria
Exclusion criteria: 1. Patients aged less than 18 years 2. Pregnant and lactating women 3. Patients refusing for consent for surgery 4. Patients who cannot undergo for MRI and PET/CT brain scans.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Through the integrated approach of molecular and functional imaging, along with histopathological and mRNA level analyses, we will identify the role of CXCR4 in GBM. We will look for the correlation of CXCR4 receptor over-expression as determined on 68Ga-Pentixafor PET/CT with in-vivo techniques and clinical outcome in GBM patients.This research may pave a way for new antagonist pharmaceutical drugs targeting CXCR4 which can be practiced in clinical use.Timepoint: Mile stones and Targets 1. Patient Enrolment, Preoperative MRI and 68Ga Pentixafor PET Scans of brain and, IHC and qRT-PCR analyses after surgery (one year) 2. Postoperative MRI and 68Ga Pentixafor PET Scans of brain after 3 months of Radiotherapy (six months) 3. MRI and 68Ga Pentixafor PET Scans of brain after one year in follow-up. (one year) 4. Data analysis and Manuscript writing (six months) | — |
Secondary
| Measure | Time frame |
|---|---|
| NILTimepoint: NIL | — |
Countries
India
Contacts
Public ContactPriya
Postgraduate Institute of Medical Education & Research, Chandigarh
Outcome results
None listed