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A study to analyse the effect of intravenous dexamethasone in pregnant females who are undergoing cesarean section under regional Anesthesia through spinal route

Evaluation of effect of intravenous dexamethasone on the duration of spinal anesthesia in parturients undergoing lower segment cesarean section (LSCS)

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041979
Enrollment
80
Registered
2022-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2023-03-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O00-O9A- Pregnancy, childbirth and the puerperium

Interventions

Intervention1: Intravenous dexamethasone: To study the effect of intravenous dexamethasone 8 mg diluted with 8 ml normal saline to be given before giving spinal anaesthesia in patients undergoing LSCS

Sponsors

Department of Anaesthesiology and Critical Care Pt B D Sharma PGIMS Rohtak
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Parturients between 20 to 35 years of age belonging to ASA (American Society of Anaesthesiologists) Grade II undergoing Lower Segment Cesarean section (LSCS) under spinal anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patient refusal. 2. Pregnancy induced hypertension. 3. Preexisting hemodynamic instability, preexisting diabetes, cardiac ailment 4. Pre-existing neuropathy or nerve block that could compromise study assessments. 5. Preoperative use of systemic corticosteroids. 6. History of allergy or hypersensitivity to local anaesthetics, dexamethasone or other drugs used in this study. 7. Any contraindication to spinal anaesthesia (coagulopathy, local infection at the site of injection). 8.Conversion to general anaesthesia

Design outcomes

Primary

MeasureTime frame
1. To determine the effect of dexamethasone on the duration of sensory block after spinal anaesthesia 2. To determine the effect of dexamethasone on the duration of motor block after spinal anaesthesia.Timepoint: Time between spinal anaesthesia and T6 or higher dermatome blockade. Maximum height of the sensory blockade attained at 20 minutes. Time of regression of sensory blockade to L1 dermatome. Time between spinal anaesthesia to Bromage score of III or higher. Maximum degree of motor blockade at 20 min. Time of regression of motor block from peak motor blockade to Bromage score of II.—

Secondary

MeasureTime frame
Duration of post-operative analgesia and complications if anyTimepoint: Time from the intrathecal injection to the time of the first complaint of pain. Blood pressure and heart rate will be recorded immediately after spinal anesthesia and then every 5 minutes till the regression of sensory block to L1 and motor block to Bromage score of II. Any episode of hypotension (fall in MAP more than 20% of baseline), bradycardia (heart rate 60 beats /min) will be recorded and managed as per standard protocol—

Countries

India

Contacts

Public ContactDr Nitika Goyal

Pt B D Sharma PGIMS, Rohtak

nitika.silk@gmail.com9877799572

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026