Skip to content

Amniotic membrane treatment in acid or alkali injury of eye

A comparative study between the efficacy of Freshly prepared amniotic membrane, Lyophilised amniotic membrane and only medical treatment in ocular burn injury in chemical factory workers of Eastern India

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041962
Enrollment
100
Registered
2022-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T266- Corrosion of cornea and conjunctival sac Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Freshly prepaired amniotic membrane patch grafting: Freshly prepaired amniotic membrane patch graft placed over chemically injured cornea and conjunctiva and sutured with 10-0 Mono fila

Sponsors

Regional Institute of Ophthalmology Kolkata
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients with ocular burn injury were selected who were present in the factory on the day of examination. 2. Ocular burn injuries within 5 days were selected. 3. According to Roper-Hall classification from Grade I to Grade IV patients are included in this study. 4. In cases where both eyes were involved, the eye with severe involvement was included. 5. Ocular burn by chemical and thermal both were included in this study. 6. In cases where both eyes were involved, the eye with severe involvement was included. 7. Patients who are willing to sign the inform consent

Exclusion criteria

Exclusion criteria: 1. Generalised burn patients had excluded. 2. Pregnant females, 3. Patients with other systemic disorders were excluded. 4. Patients with ge ,18 years were excluded 5. Visual acuity worse thann 6/60 in other eye 6. Known allergy to medications 7. No Light Perception in the affected eye 8. Any associated Mechanical Injury in the affected eye. 9. patients having burn injury more than 1 week from the day of examination 10. Patients not willing to sign the inform consent.

Design outcomes

Primary

MeasureTime frame
Time for Corneal re-epithelialisation and improvement in visual acuityTimepoint: 6 months

Secondary

MeasureTime frame
Improvement in discomfort scoreTimepoint: 6 months;Improvement in limbal ischemiaTimepoint: 6 months;Neovascularisation in central 5 mm in the corneaTimepoint: 6 months

Countries

India

Contacts

Public ContactAshis Majumdar

Purulia Government Medical College and Hospital

docjayantadutta@rediffmail.com9433571337

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026