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Comparison between olanzapine and palonosetron in decreasing nausea and vomiting after discharged from surgery

Evaluation of palonosetron and olanzapine in prevention of post discharge nausea and vomiting in selected laparoscopic surgeries ( cholecystectomy and hernia repair) - EPODS

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041930
Enrollment
180
Registered
2022-04-19
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K829- Disease of gallbladder, unspecified Health Condition 2: K469- Unspecified abdominal hernia without obstruction or gangrene

Interventions

Intervention1: inj olanzapine: inj olanzapine 5mg 30 min prior to elective surgery, patient is been evaluated for nausea and vomiting at 24 hour, 48 hour and after 7 days postoperatively Interventio

Sponsors

MAHARANI LAXMI BAI MEDICAL COLLEGE JHANSI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient undergoing elective laparoscopic cholecystectomy and hernia repair surgery

Exclusion criteria

Exclusion criteria: Mental disease, psychological issue, pregnancy, malignancy, on anti epileptic drug, surgery last for more than 2 hours, drug allergy, deranged liver function test

Design outcomes

Primary

MeasureTime frame
To evaluate the palonosetron and olanzapine in prevention of post discharged nausea and vomiting after laparoscopic surgery.Timepoint: 24hour,48hour postoperatively and 7 days after discharge—

Secondary

MeasureTime frame
prevalence of nausea and vomiting in post discharged patientTimepoint: 24hour,48hour postoperatively and 7 days after discharge;to evaluate the adverse drug reacion associated with olanzapine and palonosetronTimepoint: 24hour,48hour postoperatively and 7 days after discharge—

Countries

India

Contacts

Public ContactDr Anshul Jain

M.L.B Medical college, jhansi

dranshulrachna@gmail.com9411685406

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026