Health Condition 1: - Health Condition 2: G409- Epilepsy, unspecified
Conditions
Interventions
Intervention1: Vitamin E capsules 400mg
Comparator placebo starch 400mg: Patients will be given Vitamin E capsules 400mg or starch capsules 400mg Twice daily along with antiepileptic medication for a
Sponsors
JIPMER
Eligibility
Inclusion criteria
Inclusion criteria: 1.Adult patients of age >=18 to 2.Patients on Monotherapy with sodium valproate, Phenytoin, carbamazepine for at least a period of 6 months. 3.Patients with uncontrolled seizure (defined as having a seizure episode at least one per year when maintained on an adequate trial of antiepileptics)
Exclusion criteria
Exclusion criteria: 1. Patients with other comorbidities like renal diseases and liver diseases 2. Patients already on treatment with Vitamin E. 3. Patients with structural brain diseases and space occupying lesions as diagnosed on appropriate imaging 4. Patients not willing to give written informed consent 5. Pregnant and lactating women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary objectives 1.To estimate the changes in antioxidant levels and oxidative stress markers in patients receiving vitamin E as add-on therapy and its impact on seizure free interval when compared with placebo Timepoint: Antioxidant levels and oxidative stress markers will be assessed at baseline and every 2 months until the follow up period of 6months | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the EEG changes between both groupsTimepoint: This will be done at baseline and at 6 months | — |
Countries
India
Contacts
Public ContactDr Anusha N
JIPMER
Outcome results
None listed