Health Condition 1: M658- Other synovitis and tenosynovitis
Conditions
Interventions
Intervention1: Radiosynovectomy: Radiosynovectomy
Intervention2: Radiosynovectomy: Radiosynovectomy will be performed on the knee joint by intra-articular injection of 177-Lutetium hydroxyapatite in t
Sponsors
AIIMS Jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with refractory chronic inflammatory arthritis of the knee joint with evidence of inflammation on bone scan. 2.Patients diagnosed with rheumatoid arthritis that are unresponsive to conventional medical treatment (NSAIDs, DMARDs, and/or biologicals) for at least 6 months, with predominant knee joint involvement. 3.Patients diagnosed with osteoarthritis unresponsive to conventional medical treatment (NSAIDs) for at least 6 months. 4.Patients suffering from hemophilia with at least 2 hemarthrosis of the knee joint in the past 6 months despite use of coagulation factors.
Exclusion criteria
Exclusion criteria: 1.Pregnant or breastfeeding women 2.Women planning to get pregnant within the next 6 months 3.Children 4.Local skin infection at the injection site 5.Suspected septic arthritis 6.Intra-articular fracture 7.Ruptured popliteal cyst 8.Severe joint instability due to bone destruction 9.Patients who have undergone arthroscopy or surgery of the affected knee joint within the past 6 weeks 10.Patients who have received radiosynovectomy for the involved knee joint within the last 6 months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate pain relief in patients receiving Lutetium-177 hydroxyapatite radiosynovectomy using Visual Analogue ScaleTimepoint: At 4 weeks and 12 weeks after radiosynovectomy | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess improvement in signs of joint inflammation by bone scanTimepoint: Prior to radiosynovectomy, and at 12 weeks after radiosynovectomy;To compare the knee joint tenderness, analgesic use and mobility Timepoint: Prior to radiosynovectomy, and at 4 weeks and 12 weeks after radiosynovectomy;To evaluate the improvement in daily functioning using Oxford knee scoreTimepoint: Prior to radiosynovectomy, and at 12 weeks after radiosynovectomy | — |
Countries
India
Contacts
Public ContactTanvi Sarwal
AIIMS Jodhpur
Outcome results
None listed