Health Condition 1: N200- Calculus of kidney
Conditions
Interventions
Intervention1: preoperative antibiotic (levofloxacin) of different duration: Group II: Those receiving Tab. Levofloxacin 500 mg for a day prior to surgery (once a day) and Inj. Levofloxacin 500 mg at
Sponsors
Director PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients > 18 years of age 2.Patients with non-staghorn unilateral renal calculi 3.Patients with no indwelling ureteral stent or percutaneous nephrostomy tube in the ipsilateral or contralateral side 4.Patients with sterile mid-stream urine culture at the time of recruitment 5.Patients with a prior positive urine culture (without resistance to fluoroquinolones) in the past, but a sterile urine culture at the time of recruitment 6.Patients without symptoms of UTI, prior to intervention (PNL)
Exclusion criteria
Exclusion criteria: 1.Patients 2.Patients with immunodeficiency (e.g., HIV-AIDS, uncontrolled diabetes mellitus, immunodeficiency syndromes) 3.Patients with fever before the surgery, regardless of the initiation of pre-operative antibiotics 4.Patients unfit for general anaesthesia 5.Patients with a known potential focus of sepsis elsewhere in the body 6.Patients without the mental capacity to give consent for the procedure 7.Patients unwilling to participate in the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To observe the number of participants who develop SIRS/sepsis after PNL, following different preoperative antibiotic duration.Timepoint: 48 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the appropriate antibiotic (oral levofloxacin) duration (5 days versus 1 day) before PNL, in preventing post-PNL SIRS/urosepsis as assessed by clinical, biochemical, and microbiological parameters.Timepoint: 48 hours | — |
Countries
India
Contacts
Public ContactRohit Deshpande
PGIMER, Chandigarh
Outcome results
None listed