Health Condition 1: F840- Autistic disorder
Conditions
Interventions
Intervention1: FOLINIC ACID TABLETS: Children in this group will be given oral Folinic acid in the form of Leucovorin calcium tablet (15mg) with a target daily dose of 2mg/kg, maximum up to 50 mg/day
Sponsors
Government of National Capital Territory of Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Newly diagnosed Autism patients with language impairment ascertained on standardized tool
Exclusion criteria
Exclusion criteria: 1. Children with hearing impairment 2. Children who have received regular center based speech therapy 3. Children with DQ 4. Gross congenital malformations, children requiring antipsychotics, drugs interfering with folate metabolism 5. Clinical seizure within last 3 months 6. Gastroesophageal reflux, recurrent vomiting 7. Chronic disorders requiring frequent emergency visits 8. Weight <8 kg
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference between mean change in language quotient scores between two groups from baseline to end of 12 weeks on age appropriate subtest of standardized language scales (REEL-3 and LPT)Timepoint: Baseline and End of 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Difference between mean change of adaptive behaviour on VABS 2. Difference between mean change autism severity on CARS-2 3. Difference between mean change in social responsiveness on SRS-2 4. Difference between mean change in ATECTimepoint: Baseline and end of 12 weeks | — |
Countries
India
Contacts
Public ContactMonica Juneja
Maulana Azad Medical College
Outcome results
None listed