Health Condition 1: F122- Cannabis dependence
Conditions
Interventions
Intervention1: HD tDCS and exposure to cue: The participants will be given HD tDCS stimulation- anode at Right Dorsolateral prefrontal cortex and will be simultaneously exposed to cues in the form of
Sponsors
PGIMER Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients with a diagnosis of moderate to severe cannabis use disorders by Diagnostic and statistical Manual-5 (DSM-5) 2. We will include patients with comorbid other drug or alcohol use disorders as well 3. Providing written informed consent
Exclusion criteria
Exclusion criteria: 1. Patients with neurological disorders like multiple sclerosis, stroke, epilepsy, encephalopathy due to any cause 2. Patients with a history of significant head injury, Brain tumour or any brain surgery 3. Patients with acute psychotic illness, depressive episodes (we will recruite patients in remission) 4. Pregnant and lactating females 5. Any electronic or metal implants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Simultaneous cue-exposure and High-Definition transcranial Direct Current Stimulation (HD tDCS) is feasible and has preliminary anticraving effects in individuals with Moderate and Severe Cannabis use disorderTimepoint: baseline During each session just after last session 1 month after intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effects of combined cue-exposure and administration of HD t-DCS, administration of only HD t-DCS (exposure to neutral cues), only cue-exposure (with sham HD t-DCS), and sham stimulation (with neutral cues) for reduction of craving for cannabis, reduction of the frequency of cannabis use, duration of use, and abstinenceTimepoint: Baseline During sessions Just after session 1 month after last session;To compare the effects of combined cue-exposure and administration of HD t-DCS, administration of only HD t-DCS (exposure to neutral cues), only cue-exposure (with sham HD t-DCS), and sham stimulation (with neutral cues) for reduction of the frequency of other drug or alcohol use, duration of use, and abstinenceTimepoint: 1 month after exposure;To compare the frequency of adverse events in participants undergoing HD-tDCS and sham stimulationTimepoint: Just after last session;To evaluate the proportion of eligible participants that provide personalized cue-based images and to study the feasibility of the use of personalized cannabis cues during the cue-exposure based sessionsTimepoint: At the end of the study;To evaluate what proportion of eligible study participants, consent for the study, initiate HD t-DCS sessions, continue at least 3 sessions, and complete all six sessionsTimepoint: At the end of the study;To study the effect of HD- tDCS on cognitive functionsTimepoint: Baseline Just after last session 1 month after last session | — |
Countries
India
Contacts
Public ContactDevika Chauhan
Postgraduate Institute of Medical Education and Research
Outcome results
None listed