FindTrial
Sign In

To see the combined effect of radio frequency ablation and platelet rich plasma in treating knee osteoarthritis.

TO EVALUATE COMBINED EFFECT OF RADIOFREQUENCY ABLATION OF GENICULAR NERVE ALONG WITH INTRAARTICULAR PLATELET RICH PLASMA FOR OSTEOARTHRITIS KNEE PAIN: A PROSPECTIVE EXPLORATORY RANDOMISED CONTROL STUDY

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041790
Enrollment
60
Registered
2022-04-11
Start date
Unknown
Completion date
Unknown
Last updated
2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Radiofrequency ablation of genicular nerves along with intraarticular platelet rich plasma injection.: 1) Fluoroscopy guided radiofrequency ablation will be done upon the three genicula
then, the electrode will be inserted through the cannula and tip temperature will be raised up to 80 °C for 90 seconds per cycle. A total of 3 cycles will be given, making a total duration of 270 sec

Sponsors

ALL INDIA INSTITUTE OF MEDICAL SCIENCES RISHIKESH
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age: 18-75 years 2. Patients with symptomatic knee osteoarthritis (OA) with pain score >=6 and KL grade 1-3 that is recalcitrant to conservative modalities. 3. Patients who are not good surgical candidates because of medical comorbidities and/or a high body mass index (BMI). 4. Patients unwilling for surgery. 5. Patients who have had a previously successful genicular nerve radiofrequency ablation (GNRFA), as this procedure can be repeated to address recurrent symptomatic knee OA.

Exclusion criteria

Exclusion criteria: 1. Refusal of patient or relatives. 2. Allergic to local anaesthetic and/or radiographic contrast agent. 3. Coagulopathy or patients on anticoagulants. 4. Local site infection. 5. Pregnancy. 6. Severe psychiatric illness. 7. Red flag sign. 8. Acute knee injury. 9. Unstable knee joint. 10. Chronic pain syndrome. 11. Presence of an implantable defibrillator & Presence of a pacemaker.

Design outcomes

Primary

MeasureTime frame
To compare changes in pain scores as measured by NRS at 2,4,8 and 12 weeks with baseline value between two groups.Timepoint: At baseline, 2 weeks, 4 weeks, 8 weeks and 12 weeks.—

Secondary

MeasureTime frame
1. To compare changes in functional improvement as measured by WOMAC score at 2, 4,8,12 weeks with baseline value. 2. To evaluate and compare depression as measured by Patient health questionnaire9 (PHQ9) score at 2,4,8,12 weeks with baseline value. 3. Any adverse effects. 4. Need for rescue analgesia. 5. Likert scale for patient satisfaction. 6. Employment status Timepoint: At baseline, 2 weeks, 4 weeks, 8 weeks and 12 weeks.—

Countries

India

Contacts

Public ContactSHIWAM KUMAR GUPTA

AIIMS, RISHIKESH

praveenrt64@gmail.com9654162941

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026