Health Condition 1: J850- Gangrene and necrosis of lung Health Condition 2: O- Medical and Surgical Health Condition 3: J841- Other interstitial pulmonary diseases with fibrosis
Conditions
Interventions
Intervention1: Deferasirox: Deferasirox 500mg tablet on the night before surgery dissolved in 100ml plain water
Control Intervention1: Glucose tablet: One tablet on the night before surgery dissolved
Sponsors
King Georges Medical University
Eligibility
Inclusion criteria
Inclusion criteria: Elective thoracic surgery on one lung ventilation requiring lung seperation using Double Lumen Tube
Exclusion criteria
Exclusion criteria: Refusal to give consent Bilateral lung disease Cardiovascular disease Renal or hepatic disease Allergy to study medication Obesity and pregnant patients
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Difference in Shunt FractionTimepoint: 1. Baseline 2. 10 minutes , 20 minutes ,30 minutes after initiation of One Lung Ventilation 3. 6 hours postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Differences in : 1.Number of desaturation episodes 2.Partial pressure of oxygen 3.Arterial blood saturation 4.Ratio of arterial oxygen partial pressure to fractional inspired oxygen 5.Alveolar arterial gradientTimepoint: All of these will be measured at 1. Baseline 2. 10 minutes , 20 minutes ,30 minutes after initiation of One Lung Ventilation 3. 6 hours postoperatively | — |
Countries
India
Contacts
Public ContactParvathy S Nair
King Georges Medical University
Outcome results
None listed