Improvement of healing by Mitomycin in Oral Sumucous Fibrosis Patients after surgery

Efficacy of topical 0.02% Mitomycin in improving healing in Oral Submucous fibrosis bands and reconstruction with buccal fat pad- a split mouth pilot study

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/04/041738

Enrollment

Registered

2022-04-08

Start date

Unknown

Completion date

Unknown

Last updated

2022-05-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K135- Oral submucous fibrosis

Interventions

Intervention1: MITOMYCIN: 0.02% MITOMYCIN USED ON RAW SURFACE FOR 5 MINUTES AND THEN WASHED WITH 30 ML SALINE, THEN AFTER 10 DAYS, IT IS USED AGAIN FOR 3 MINUTES AND WASHED OFF Control Intervention1:

Eligibility

Inclusion criteria

Inclusion criteria: ASA I,II MOUTH OPENING LESS THAN 25 mm

Exclusion criteria

Exclusion criteria: PREGNANT AND LACTATING FEMALES MOUTH OPENING GRETAER THAN 25 MM Any malignant chnages with OSMF Non compliant patient

Design outcomes

Primary

Measure	Time frame
degree of mucolisation and fibrosisTimepoint: pre operative, 1 week postoperative, 1 month postoperative and 3 months postoperative	—

Secondary

Measure	Time frame
1. vas score by the patient for degree of hardness felt 2. colour and consistency of mucosa 3. areas of postoperative fibrosisTimepoint: pre operative, 1 week postoperative, 1 month postoperative and 3 months postoperative	—

Countries

India

Contacts

Public ContactAnkita Chugh

AIIMS,Jodhpur

ankitamody@gmail.com8003996891

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026