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Detecting if Change in the exhaled Carbon Dioxide signifies change in Cardiac output for the prediction of response to fluids in adult patients undergoing cancer surgery

Detecting if Change in End tidal Carbon dioxide (delta ETCO2) signifies change in Cardiac Output for the preDiction of fluid rEsponsiveness in adult patients undergoing major non-thoracic oncosurgery: DECODE, An observational study - DECODE

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/04/041695
Enrollment
22
Registered
2022-04-06
Start date
Unknown
Completion date
Unknown
Last updated
2023-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C189- Malignant neoplasm of colon, unspecified Health Condition 2: C229- Malignant neoplasm of liver, not specified as primary or secondary Health Condition 3: C259- Malignant neoplasm of pancreas, unspecified Health Condition 4: C20- Malignant neoplasm of rectum Health Condition 5: C169- Malignant neoplasm of stomach, unspecified Health Condition 6: C569- Malignant neoplasm of unspecifiedovary Health Condition 7: C55- Malignant neoplasm of uterus, partunspecified

Interventions

None listed

Sponsors

Sohan Lal Solanki
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Adult (Age 18 and above) 2. Giving informed consent 3. ASA PS 1, 2, 3 4. Planned for surgeries routinely requiring radial artery cannulation and the FlotracTM and Vigileo EV1000 / Volumeview cardiac output monitor for perioperative care used as a part of routine intraoperative management

Exclusion criteria

Exclusion criteria: 1. Planned for open thoracic surgery 2. History of Cardiac arrhythmias/ intraoperative Cardiac arrhythmias 3. Heart failure: both systolic and diastolic heart failure (with or without reduced Left ventricular ejection fraction) 4. Severe restrictive/obstructive lung disease (MRC score 3 and above)

Design outcomes

Primary

MeasureTime frame
to determine whether the delta ETCO2 after a fluid challenge test identifies fluid responsiveness, i.e., increase in stroke volume index (dSVI) and Cardiac Index (dCI) 10%.Timepoint: After 1 minute of fluid boluses over 10 minutes.—

Secondary

MeasureTime frame
To compare the ability to delta ETCO2 to discriminate between fluid responders and non-responders with that of PPV and Stroke Volume Variation (SVV)Timepoint: After 1 minute of fluid boluses over 10 minutes.—

Countries

India

Contacts

Public ContactShreyas Chawathey

Tata Memorial Hospital, Mumbai

sohan.solanki@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026