Health Condition 1: J189- Pneumonia, unspecified organism
Conditions
Interventions
Intervention1: resB® Lung Support: Receiving resB® Lung Support capsule twice daily orally for 14 days from enrolment
Control Intervention1: Placebo: Receiving placebo capsules twice daily for 14 da
Sponsors
ResBiotic Nutrition
Eligibility
Inclusion criteria
Inclusion criteria: Elderly patients (age > 60 years) admitted to the various ICUs / Emergency Department of AIIMS, Bhubaneswar who provide a valid informed consent for participation in the trial
Exclusion criteria
Exclusion criteria: 1. Any contraindications for enteral feeding during the proposed study period 2. Any contraindications for broncho-alveolar lavage 3. Patients with intestinal diversions and stoma and diagnosed anatomical abnormalities of the GI tract like muco-cutaneous fistulae, etc. 4. Patients with hematological malignancies, infected with hemo-parasites or lymphotropic organisms. 5. Patients with chest trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence and Prognosis in elderly pneumonia admitted to acute care set-up with and without resB® Lung SupportTimepoint: A longitudinal assessment of incidence during the entire duration of the study Prognosis will be assessed upto 30 days of recruitment | — |
Secondary
| Measure | Time frame |
|---|---|
| Characterizing the microbial composition in the broncho- pulmonary aspirates Timepoint: â?¢ Within 24 hours of admission and enrolment â?¢ After 14 completed days of interventional supplementation â?¢ After 30 completed days since initiation of interventional supplementation/ hospital discharge â?? whichever is earlier;Evaluating any change in the gut microbial composition from stool sample analysis Timepoint: â?¢ Within 24 hours of admission and enrolment â?¢ After 14 completed days of interventional supplementation â?¢ After 30 completed days since initiation of interventional supplementation/ hospital discharge â?? whichever is earlier;Measuring the levels of total small chain fatty acids in the stool sampleTimepoint: â?¢ Within 24 hours of admission and enrolment â?¢ After 14 completed days of interventional supplementation â?¢ After 30 completed days since initiation of interventional supplementation/ hospital discharge â?? whichever is earlier;Measuring the secretory IgA levels in the bronchopulmonary secretions and blood samples Timepoint: â?¢ Within 24 hours of admission and enrolment â?¢ After 14 completed days of interventional supplementation â?¢ After 30 completed days since initiation of interventional supplementation/ hospital discharge â?? whichever is earlier | — |
Countries
India
Contacts
Public ContactDr Jayanta Kumar Mitra
AIIMS-Bhubaneswar
Outcome results
None listed