Health Condition 1: F429- Obsessive-compulsive disorder, unspecified
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Medical Research Unit
Eligibility
Inclusion criteria
Inclusion criteria: i. Meeting the criteria of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) presented by the American Psychiatric Association (Washington, D.C., USA) ii. Aged between 16 and 50 years old iii. A YaleBrown Obsessive-Compulsive Scale (Y-BOCS) score >16 points; for simple obsessive or forced behavior, a Y-BOCS score >8 points. iv. No other major mental illnesses. v. No history of psychiatric drug use. vi. Give written informed consent.
Exclusion criteria
Exclusion criteria: i. A history of organic brain disease or serious physical illness, symptoms of psychosis, or a history of other mental illnesses ii. Severe depression (a Hamilton Depression Rating Scale (HAMD) score >35 points) iii. Second-generation with a family history of mental illness.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To assess alteration in plasma levels of miRNA-132 in patients with obsessive-compulsive disorder before and after treatment 2. To assess alteration in plasma levels of miRNA-134 in patients with obsessive-compulsive disorder before and after treatmentTimepoint: 24 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To find correlation between levels of miRNA-132 and clinical indicators before and after treatment. 2. To find correlation between levels of miRNA-134 and clinical indicators before and after treatment.Timepoint: 24 weeks | — |
Countries
India
Contacts
Public ContactDr Amit Jain
Guru Gobind Singh Medical College
Outcome results
None listed