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Dexamethasone, Paracetamol and Ketorolac combination for pain relief and opioid sparing effects in total laparoscopic hysterectomy

To compare the opioid sparing effects Of combination Of dexamethasone , paracetamol and ketorolac(DexPak) VS paracetamol , ketorolac in patients undergoing total laparoscopic hysterectomy: a prospective double blind randomized controlled trial.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041624
Enrollment
100
Registered
2022-04-04
Start date
Unknown
Completion date
Unknown
Last updated
2023-09-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N859- Noninflammatory disorder of uterus, unspecified

Interventions

Intervention1: Dexamethasone 0.2mg/kg ,ketorolac 30mg, Paracetamol1g: Intravenous Dexamethasone will be given 1 hour before surgery. Intravenous Paracetamol and ketorolac will be given before inductio

Sponsors

Parin Lalwani
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients of ASA physical status I and II posted for elective total laparoscopic hysterectomy

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. Known allergy to the drugs 3. History of chronic analgesic or steroid consumption 4. History of gastric or duodenal ulcer 5. BMI >30 6. History of asthma 7. History of diabetes mellitus 8. History of endometriosis 9. Chronic alcoholism 10. Liver and/or kidney dysfunction 11. Limitations in understanding use of PCA pump 12. Duration of surgery >2 hrs / converted to open surger

Design outcomes

Primary

MeasureTime frame
Total intravenous Patient controlled analgesia(PCA) fentanyl consumption in the first 24 hours postoperativelyTimepoint: 24 hours postoperatively—

Secondary

MeasureTime frame
1. Time for first analgesic requirementTimepoint: 24 hours postoperatively;2. Post operative pain scores at rest and during movement 0min 15min 30min 1,2,4,8,12 and 24 hours postoperatively Timepoint: 0min, 15min, 30min , 1,2,4,8,12,24 hours;Post operative nausea and vomitingTimepoint: 0min, 15min, 30min , 1,2,4,8,12,24 hours;Wound healingTimepoint: 7 days postoperatively—

Countries

India

Contacts

Public ContactIsha Nene

All India Institute of Medical sciences

drparinlalwani@gmail.com9650533388

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026