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To compare the effects of ventilatory strategies on oxygenation in patients undergoing lower abdominal laparoscopic surgeries.

To compare the effects of standard vs transpulmonary pressure guided intraoperative PEEP on postoperative PaO2/FiO2 ratio in patients undergoing laparoscopic lower abdominal surgeries.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/04/041566
Enrollment
70
Registered
2022-04-01
Start date
Unknown
Completion date
Unknown
Last updated
2022-10-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: J00-J99- Diseases of the respiratory system Health Condition 2: 4- Measurement and Monitoring Health Condition 3: N859- Noninflammatory disorder of uterus, unspecified

Interventions

Intervention1: Transpulmonary pressure guided PEEP titration.: The control group will be given low tidal volume combined with standard PEEP while the other group will be given PEEP titrated as per tra

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Male and female patients aged more than 18 years, undergoing elective laparoscopic lower abdominal surgeries in AIIMS, New Delhi.

Exclusion criteria

Exclusion criteria: Patient refusal Emergency surgeries History of any prior lung surgeries Pregnancy Contraindications to nasogastric tube placement Any nasopharyngeal or oropharyngeal pathologies Any laparoscopic surgery being converted to open surgery

Design outcomes

Primary

MeasureTime frame
PaO2/FiO2 ratio 30 minutes after extubation.Timepoint: 30 minutes after extubation.—

Secondary

MeasureTime frame
Difference in hemodynamicsTimepoint: Post intubation, while giving recruitment manoeuvre, after positioning and pneumoperitoneum creation, 1 hour after recruitment manoeuvre;Difference in partial pressure of oxygen P(A-a) gradient after PEEP titration and extubationTimepoint: Pre intubation, post intubation, 1 hour after recruitment manoeuvre;Lung atelectasis 30 minutes after extubationTimepoint: After extubation;PaO2/FiO2 ratio after PEEP titrationTimepoint: 1 hour after recruitment manoeuvre;Respiratory system complianceTimepoint: Post intubation,while giving recruitment manoeuvre, after positioning and pneumoperitoneum creation, 1 hour after recruitment manoeuvre.—

Countries

India

Contacts

Public ContactDr Atma Pradeep

AIIMS

drrahulkanand@gmail.com9013082271

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026