Health Condition 1: O- Medical and Surgical Health Condition 2: H178- Other corneal scars and opacities
Conditions
Interventions
Intervention1: Umbilical Cord Patch Graft: Umbilical Cord patch will be grafted over the corneal perforation and will be sutured with the cornea with 8 radial (10 - 0) monofilament nylon
Control Inter
Sponsors
Regional Institute of Ophthalmology Kolkata
Eligibility
Inclusion criteria
Inclusion criteria: 1. Subjects with a known case of corneal perforation and descemetocele due to both infectious and non-infectious cause 2. Subjects with corneal perforation due to trauma 3. Subjects with corneal perforation size between 3.5 to 5.5 mm in diameter. 4. Patients with no previous history of keratoplasty 5. In case of bilateral cases, the severely affected eye is included 6. Patients who are willing to sign the informed consent
Exclusion criteria
Exclusion criteria: 1. Corneal perforation 2. Any active corneal infection 3. Corneal scar not easily distinguishable from a current ulcer. 4. Previous penetrating keratoplasty in the affected eye. 5. 6. Pregnancy (by history or urine test) or breast-feeding. 7. Acuity worse than 6/60 (20/200) in the other eye. 8. Known allergy to medications (antibiotics or preservatives). 9. No light perception in the affected eye 10. Patients who are not willing to sign the consent form
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Umbilibal Cord patch graft integrity with the host cornea and whether there is any graft thiningTimepoint: 6 months | — |
Secondary
| Measure | Time frame |
|---|---|
| Anterior chamber reactionTimepoint: 1 month;Changes in Anterior chamber depth with respect to fellow eyeTimepoint: 6 months;Changes in Intraocular pressure with the fellow eyeTimepoint: 6 months;Conjunctival Injection scoreTimepoint: 1 month;Improvement in Visual AcuityTimepoint: 6 months;Patient discomfort scoreTimepoint: 1 month;Time for complete re-epithelializationTimepoint: 1 month | — |
Countries
India
Contacts
Public ContactAshis Majumdar
Government Medical College & Hospital, Purulia
Outcome results
None listed