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Radiation induced gene expression changes in the blood samples of cancer patients with and without diabetes undergoing radiotherapy

Influence of diabetes on radiation induced gene expression changes in cancer patients undergoing radiotherapy

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/03/041458
Enrollment
180
Registered
2022-03-29
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms Health Condition 2: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Nil: Nil

Sponsors

Venkateswarlu Raavi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Type 2 Diabetic patients without complications 2. Head and Neck cancer patients (with and without diabetes) undergoing radiotherapy 3. No known exposure to medical radiation exposure prior one month 4. Healthy volunteers

Exclusion criteria

Exclusion criteria: 1. Pregnant women 2. Individual with a known family history of genetic diseases 3. Patients already treated for cancer 4. Patients with comorbidities (apart from diabetes)

Design outcomes

Primary

MeasureTime frame
The information on baseline expressions of selective genes, factors influencing the base line expression, influence of diabetic condition will be helpful for better utilization of these gene expression markers for the measurement of both normal tissue toxicity and better management of radiotherapyTimepoint: After completion of 2 years

Secondary

MeasureTime frame
The information on baseline expressions of genes, factors influencing the base line expression, influence of diabetic condition will also be useful for better utilization of these gene expression markers for radiation biodosimetryTimepoint: After completion of 2 years

Countries

India

Contacts

Public ContactVENKATESWARLU RAAVI

Sri Devaraj Urs Academy of Higher Education and Research (Deemed to be University)

venkyneuro@gmail.com91-9952016269

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026