Induced hypotension for endoscopic sinus surgery

Comparison of Hypotensive Properties of Clonidine versus Esmolol for Induced Hypotension During Functional Endoscopic Sinus Surgery: A prospective randomized interventional study at sms medical college ,Jaipur during 2021-2023

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041451

Enrollment

Registered

2022-03-29

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Clonidine: Clonidine will be administered 10 min before induction as a loading dose, followed by infusion till the end of the surgery Control Intervention1: esmolol: Esmolol will be adm

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade I & II Body Weight 45 to 65 kgs Undergoing elective resection pf nasal polyp

Exclusion criteria

Exclusion criteria: H/o of allergies to Esmolol/Clonidine Patient with preexisting bleeding/coagulopathy h/o Hypertemnsion, CAD, Renal and hepatic dysfunction, cerebral insufficiency Patient refusing to consent H/o recurrent sinus surgeries Orbital abscess CSF leak with/without CSF Rhinorrhea

Design outcomes

Primary

Measure	Time frame
Mean Arterial Blood Pressure, Systolic BP, DBPTimepoint: baseline, after loading dose, after induction, 1 min after intubation, 5 min after intubation, 10 min after intubation , every 10 min thereafter, unto 70 min	—

Secondary

Measure	Time frame
Heart RateTimepoint: baseline, after loading dose, after induction, 1 min after intubation, 5 min after intubation, 10 min after intubation , every 10 min thereafter, unto 70 min;Intraoperative bleedingTimepoint: 5 min from starting of the surgery, 10 min, every 10 min , unto 70 min;Mean emergence timeTimepoint: postoperatively at 0 min, then every 30 min unto 240 min;Median VAS scoreTimepoint: Postoperatively, 0 Min, every 30 minuet 240 min;Sedation ScoreTimepoint: Postoperative 0 min, then every 30 min , unto 240 min;SpO2Timepoint: Baseline, After loading dose, after induction, 1 min after intubation, 5 min, 10 min, then every 10 min unto 70 min	—

Measure

Time frame

Heart RateTimepoint: baseline, after loading dose, after induction, 1 min after intubation, 5 min after intubation, 10 min after intubation , every 10 min thereafter, unto 70 min;Intraoperative bleedingTimepoint: 5 min from starting of the surgery, 10 min, every 10 min , unto 70 min;Mean emergence timeTimepoint: postoperatively at 0 min, then every 30 min unto 240 min;Median VAS scoreTimepoint: Postoperatively, 0 Min, every 30 minuet 240 min;Sedation ScoreTimepoint: Postoperative 0 min, then every 30 min , unto 240 min;SpO2Timepoint: Baseline, After loading dose, after induction, 1 min after intubation, 5 min, 10 min, then every 10 min unto 70 min

—

Countries

India

Contacts

Public ContactDr Komal Garg

Sawai Man Singh Medical College

bafnausha@yahoo.com01412518680

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026