Health Condition 1: R57- Shock, not elsewhere classified
Conditions
Interventions
Intervention1: 10 ml/kg of 0.9% saline: Fluid bolus volume of 10ml/kg of 0.9% saline administered during fluid resuscitation over 10-20 minutes
Control Intervention1: 20 ml/kg of 0.9% saline: Fluid bo
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: Children presenting to the emergency department with septic shock. septic shock is defined as: Suspected or confirmed infection with SIRS and one or more of the following: Capillary refill time of 3 or more seconds, weak radial-pulse volume, other signs of poor perfusion as per treating clinician, hypotension
Exclusion criteria
Exclusion criteria: 1. Cardiopulmonary resuscitation 2. Severe anemia with congestive cardiac failure 3. Transfer from another hospital with prior fluid resuscitation 4. Known congenital heart disease 5. Raised intracranial pressure
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need for invasive ventilation and/or 25% worsening in oxygenation parametersTimepoint: At 6 hours | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of resolution of shockTimepoint: At any point during hospital stay;Fluid overload% (FO%)Timepoint: at 24 hours, 48 hours and 72 hours;In hospital mortalityTimepoint: At any point during hospital stay;Resolution of shockTimepoint: At 6 hours | — |
Countries
India
Contacts
Public ContactJayashree Muralidharan
PGIMER
Outcome results
None listed