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Is Early Post Operative Chemotherapy a feasible alternative to Hyperthermic Intra Peritoneal Chemotherapy ?

A Pilot Randomisation Study Comparing perioperative outcomes between Hyperthermic Intraperitoneal Chemotherapy (HIPEC) and Early Postoperative Intraperitoneal Chemotherapy (EPIC) with Audit and Analysis of Peritoneal Surface Malignancy Database.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/03/041388
Enrollment
40
Registered
2022-03-25
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C569- Malignant neoplasm of unspecifiedovary Health Condition 2: C569- Malignant neoplasm of unspecifiedovary

Interventions

Intervention1: EPIC ( Early post operative intraperitoneal chemotherapy): Intra peritoneal chemotherapy administered via surgically placed drains on post operative days 1-5. Control Intervention1: Hyp

Sponsors

All India Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age 18year to 70 years. Epithelial ovarian, fallopian tube or primary peritoneal cancer histology Stage 3 and stage 4 disease as per ovarian cancer staging AJCC-TNM 8th edition. Received Neoadjuvant chemotherapy Performance status â?? ECOG :1 or optimized ECOG: 2. Patients willing for regular follow-up.

Exclusion criteria

Exclusion criteria: Patients received chemotherapy in another hospital before visiting the centre. Second primary cancer. Poor general condition (unlikely to tolerate or complete the proposed treatment course). Patients unwilling to give consent

Design outcomes

Primary

MeasureTime frame
To study perioperative morbidity and mortality, side effect and toxicity profile in advanced epithelial ovarian, fallopian, primary peritoneal cancer undergoing Cytoreductive surgery with Early Postoperative Intraperitoneal Chemotherapy or Hyperthermic Intra Peritoneal Chemotherapy.Timepoint: 2 months post surgery—

Secondary

MeasureTime frame
To study the quality of life in advanced epithelial ovarian, fallopian, primary peritoneal cancer undergoing interval cytoreduction with Early Postoperative Intraperitoneal Chemotherapy or Hyperthermic Intra Peritoneal ChemotherapyTimepoint: 2 months post op—

Countries

India

Contacts

Public ContactTalluri Sri Harsha Vardhan Surya

all india institute of medical sciences

major.mdray@gmail.com

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026