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A clinical trial to study the effects of curcumin gel in the management of gum disease.

Effect of 1 % curcumin gel on interleukin-6 levels in the gingival crevicular fluid of chronic periodontitis patients - A polymerase chain reaction study.

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/03/041339
Enrollment
40
Registered
2022-03-24
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: 1 % CURCUMIN GEL: 1 % CURCUMIN GEL IS PLACED ONCE PER PATIENT AT BASELINE. DURATION OF THE TREATMENT IS 21 DAYS Control Intervention1: tetracycline fiber (Periodontal plus AB): tetracyc

Sponsors

Dr Lekshmi R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients diagnosed with chronic periodontitis. 2) Patients willing to take part in the study. 3) Patients in the age group 30 to 65 years without systemic disease. 4) Patients with atleast 20 natural teeth. 5) Patients with periodontal pocket depth of >4mm to 8mm with radiological evidence of bone loss. 6) No history of allergy. 7) Patients willing to take part in the study, and willing to turn up after 21 days and signed on the informed consent.

Exclusion criteria

Exclusion criteria: 1) Pregnant and lactating women. 2) Teeth with endo-perio lesions. 3) Patients used tobacco or tobacco related products. 4) Patients under antibiotic therapy within 3 months of time period from the study. 5) Patients with h/o systemic diseases that can affect the periodontal status 6) Patients who have undergone periodontal surgery. 7) Patients using mouthwash regularly 8) Patients diagnosed with aggressive periodontitis 9) Patients allergic to curcumin and tetracycline

Design outcomes

Primary

MeasureTime frame
CHECKING THE EFFECT OF 1% CURCUMIN GEL ON IL-6 LEVELSTimepoint: AT THE BASELINE VISIT AND AT 21 DAYS

Secondary

MeasureTime frame
CHANGES IN PLAQUE INDEX(PI),GINGIVAL INDEX(GI), GINGIVAL BLEEDING INDEX(GBI),PROBING POCKET DEPTH(PPD) AND CLINICAL ATTACHMENT LEVEL (CAL) WILL BE DOCUMENTED Timepoint: AT THE BASELINE VISIT AND AT 21 DAYS;CHECKING THE EFFECT OF TETRACYCLINE FIBERS ON IL-6 LEVELSTimepoint: AT THE BASELINE VISIT AND AT 21 DAYS

Countries

India

Contacts

Public ContactDr Krishna Kripal

RAJARAJESWARI DENTAL COLLEGE AND HOSPITAL

kripalkrishna@yahoo.com9632597504

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026