A study to compare between medications which are Tablet clonidine and Tablet Pregabaline for their effect on decreasing the anxiety of the patient and their effect on maintaining blood pressure of the patient so that there will be very minimal blood loss during surgery

Comparative study of Clonidine Versus Pregabalin as a premedication for preoperative sedation, anxiolysis and to attain oligemic field in Ear Nose and Throat surgeries: A prospective randomized double blind study

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041299

Enrollment

100

Registered

2022-03-23

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Premedication with Tablet Clonidine and Pregabaline: Pt is given Tablet clonidine and Pregabaline as a premedication 90minutes before surgery and the effects of each drug is compared Co

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective Ear nose and throat surgeries 2.Patient conformed to American society of anaesthesilogy physical status i and ii 3.Patients belonging to mallampatti grading i and ii on airway asessment

Exclusion criteria

Exclusion criteria: Inability or refusal to follow the study protocol. 2. Patients with H/o Diabetes mellitus, Hypertension, Arrhythmias, liver and kidney disorders, cerebral disease, epilepsy. 3. Patients with hypotension and shock 4. Patients with BMI > 30 kg/m2 5. Patients on sedatives/hypnotics. 6.Patients with coagulation disorders. 7. Patients allergic to Pregabalin or Clonidine.

Design outcomes

Primary

Measure	Time frame
sedation and anxiolysis produced by two drugs in the study And minimal blood in surgical field so that surgery will be easy to carryoutTimepoint: Sedation(Ramsay sedation scorre) and anxiolysis score are assessed before surgery Blood pressure and other vital parameters are assessed through surgery and noted every 15minutes And ISOFE score(Intraoperative surgical field evaluation score)noted during surgery every half hourly	—

Measure

Time frame

sedation and anxiolysis produced by two drugs in the study And minimal blood in surgical field so that surgery will be easy to carryoutTimepoint: Sedation(Ramsay sedation scorre) and anxiolysis score are assessed before surgery Blood pressure and other vital parameters are assessed through surgery and noted every 15minutes And ISOFE score(Intraoperative surgical field evaluation score)noted during surgery every half hourly

—

Secondary

Measure	Time frame
1.To monitor HR (per minute), Mean Arterial pressure (MAP),Systolic and diastolic blood pressure (SBP &DBP), Peripheral oxygen saturation (SPO2). 2. To look for any side effects in patients receiving these drugs.Timepoint: 90 minutes before surgery till 4hours after surgery	—

Countries

India

Contacts

Public ContactDr Swati Bhatt

Government Medical college, Vadodara

drswatibhatt2015@yahoo.com9879372038

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026