Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: High FiO2(0.8): Inra-Operative high FiO2 will be used throughout the surgery.
Duration:from start of surgery till the end.
Control Intervention1: Standard FiO2(0.3-0.4): Standard FiO2 o
Sponsors
Dr Souvik Maitra
Eligibility
Inclusion criteria
Inclusion criteria: Adult patients (aged between 18 years and 75 years) of American Society of Anesthesiologists physical status I or II, of either sex undergoing elective or emergency abdominal surgery with duration more than 2 hours under general anesthesia will be recruited in this study
Exclusion criteria
Exclusion criteria: 1. Patients refusal to participate in the study 2. Patients undergoing emergency laparotomy for trauma and related causes. 3. Known COPD or other chronic lung diseases 4. Preoperative diagnosis of Pneumonia 5. Known deformity of chest wall or thoracic spine 6. Pre-existing significant cardiac, renal and hepatic diseases 7. Intraoperative massive blood loss (defined by blood loss >40 ml/kg) or massive transfusion (more than 8 unit of PRBC transfusion during surgery) 8. Patients with history of previous thoracic surgery. 9. BMI > 30 kg/m2, 10. Patients who are on high dose of vasopressors (defined as noradrenalin 10mcg/m or equivalent)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to identify whether High FiO2 with PEEP titration is Non-Inferior to standard FiO2 in terms of incidence of POPC up to 5 days after surgery.Timepoint: Postoperative day 3 & 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| . Platelet- neutrophil ration and neutrophil- lymphocyte ratioTimepoint: Post-Operative day1;1. SpO2 at room airTimepoint: one hour post-surgery and after 24 hours;Days alive without antibioticTimepoint: Day 28;Duration of hospital stayTimepoint: At hospital discharge;Surgical site infectionTimepoint: Postoperative day 5 or hospital discharge | — |
Countries
India
Contacts
Public ContactDr Jose Cyriac kochupurackal
AIIMS
Outcome results
None listed