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Comparasion of Dexamethasone and Dexmedetomidine as an additive to Lignocaine in Inferior Alveolar Nerve Block in reducing pain after lower impacted third molar surgery

Comparative Effectiveness of Dexamethasone and Dexmedetomidine as an Adjunct to Lignocaine in Inferior Alveolar Nerve Block to reduce postoperative inflammatory response among patients undergoing lower impacted third molar surgery

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/03/041276
Enrollment
70
Registered
2022-03-22
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: dexamethasone: Dexamethasone, a steroid, is invariably used in controlling postoperative pain, edema and trismus in lower third molar surgery. 2.0 ml of 2 % lignocaine with 1:80,000 adr

Sponsors

Sharad Pawar Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Individuals with ASA Group I status 2. Individuals between 18 to 40 years 3. Presence of unilateral Impacted Mandibular Third Molar having moderate to difficult, difficulty index (Modified Pedersonâ??s Scoring)

Exclusion criteria

Exclusion criteria: 1. History of drug dependence 2. Patients with systemic disease such as HTN, DM, blood dyscrasias, immunocompromised status. 3. Patients who chronic smokers 4. Patients on cardioselective antihypertensive drugs. 5. Patients with allergy to local anaesthetic agents used in the study 6. Pregnant and nursing mothers 7. Females on oral contraceptives 8. Patients undergoing treatment with antibiotics, anti-inflammatory drugs 9. Presence of any local infection like pericoronitis/pterygomandibular space infection 10. Presence of any persistent facial pain on the intervention side 11. Radiologic evidence of Inferior alveolar canal approximation 12. Patients with Congenital Heart Disease. 13. Patients who are have any psychiatric illness.

Design outcomes

Primary

MeasureTime frame
1)Duration of postoperative analgesia 2)Latency /Onset of anaesthesia 3) Pain threshold 4) Post-operative severity of trismus 5) Post-operative extent of facial swelling 6) Pain measurement at specified intervals 7) Measurement of pain and physical quality of life using PoSSe Scale 8) Number of analgesics consumedTimepoint: At baseline, 2nd day and 7th day—

Secondary

MeasureTime frame
Post-operative extent of facial swelling 6) Pain measurement at specified intervals 7) Measurement of pain and physical quality of life using PoSSe Scale 8) Number of analgesics consumedTimepoint: intra-operative, immediate post operative, 2nd and 7th day—

Countries

India

Contacts

Public ContactAkhil Ashok Sharma

DATTA MEGHE INSTITUTE OF MEDICAL SCIENCES

anendd.j@gmail.com09623399911

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026