Health Condition 1: K729- Hepatic failure, unspecified
Conditions
Interventions
Intervention1: Rifaximin with antibiotics: Rifaximin 550 mg twice daily
Control Intervention1: antibiotics: Only antibiotics as per hospital policy
Sponsors
AIG Hospitals
Eligibility
Inclusion criteria
Inclusion criteria: liver disease patients admitted to the high dependency unit or intensive care unit above the age of 18 with a primary diagnosis of hepatic encephalopathy irrespective of the precipitant.
Exclusion criteria
Exclusion criteria: acute liver failure other causes of encephalopathy (ex: uremic encephalopathy - S. urea > 150) patients with underlying chronic renal failure patients on antidepressants or sedatives underlying neuropsychiatric conditions history of alcohol consumption of less than one week patients who died within 24 hours of admission patients who refused to participate in the study patients below the age of 18
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the proportion of patients achieving 2-grade reduction of HE (as measured by the West Haven criteria) and/or complete resolution of HE between the two armsTimepoint: during the hospital stay | — |
Secondary
| Measure | Time frame |
|---|---|
| in-hospital mortality in both the armsTimepoint: during the hospital stay;duration of hospital stay in both armsTimepoint: duration of hospital stay;incidence of nosocomial (new-onset in-hospital) infectionTimepoint: during the hospital stay;time taken for resolution of infection (if any) Timepoint: during the hospital stay;Time taken to resolution of HE in both arms Timepoint: during the hospital stay;To compare endotoxin levels at diagnosis and at the resolution of HE between both arms Timepoint: during the hospital stay | — |
Countries
India
Contacts
Public ContactAnand V Kulkarni
AIG Hospitals
Outcome results
None listed