Early versus conventional start of dialysis in children with acute kidney disease

Early versus conventional initiation of RRT in children with Acute kidney Injury: A Randomized controlled trial - ECARRT

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041209

Enrollment

Registered

2022-03-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N179- Acute kidney failure, unspecified

Interventions

Intervention1: RRT: Early versus late initiation of RRT Control Intervention1: Timing of initiation of RRT- early versus late: Children with AKI satisfying the inclusion and exclusion criteria will be

Eligibility

Inclusion criteria

Inclusion criteria: Critically ill children from 6 months to <16 years of age with acute kidney injury stage 3 defined by KDIGO criteria

Exclusion criteria

Exclusion criteria: Children already initiated on RRT, Fluid overload > 10-15%, Severe metabolic acidosis pH 6.0 mEq/L refractory to medical management, Uremic encephalopathy, Inborn errors of metabolism/ Intoxication/ poisoning where hemodialysis is required urgently

Design outcomes

Primary

Measure	Time frame
All-cause mortality at 90 daysTimepoint: All-cause mortality at 90 days	—

Secondary

Measure	Time frame
Mortality at 28 daysTimepoint: Mortality at 28 days;Requirement of RRT in the conventional groupTimepoint: Requirement of RRT in the conventional group;Median length of ICU stayTimepoint: Median length of ICU stay;Median duration of ventilationTimepoint: Median duration of ventilation;Median duration of inotropesTimepoint: Median duration of inotropes;Median length of hospital stayTimepoint: Median length of hospital stay;Incidence of catheter related nosocomial infectionTimepoint: Incidence of catheter related nosocomial infection;Improvement in the pSOFA score in both the groupsTimepoint: Improvement in the pSOFA score in both the groups;Dependency on RRT at 60 days / mean duration of RRTTimepoint: Dependency on RRT at 60 days / mean duration of RRT;eGFR, ACR and blood pressure at 90 daysTimepoint: eGFR, ACR and blood pressure at 90 days	—

Measure

Time frame

Mortality at 28 daysTimepoint: Mortality at 28 days;Requirement of RRT in the conventional groupTimepoint: Requirement of RRT in the conventional group;Median length of ICU stayTimepoint: Median length of ICU stay;Median duration of ventilationTimepoint: Median duration of ventilation;Median duration of inotropesTimepoint: Median duration of inotropes;Median length of hospital stayTimepoint: Median length of hospital stay;Incidence of catheter related nosocomial infectionTimepoint: Incidence of catheter related nosocomial infection;Improvement in the pSOFA score in both the groupsTimepoint: Improvement in the pSOFA score in both the groups;Dependency on RRT at 60 days / mean duration of RRTTimepoint: Dependency on RRT at 60 days / mean duration of RRT;eGFR, ACR and blood pressure at 90 daysTimepoint: eGFR, ACR and blood pressure at 90 days

—

Countries

India

Contacts

Public ContactKambagiri Pratyusha

ALL INDIA INSTITUTE OF MEDICAL SCIENCES- RAIPUR

dratuljindal@gmail.com8224014667

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026