A study to compare and evaluate wound healing outcome of superoxidised solution and calendula officinalis flower extract used for local wound care in patients of oral squamous cell carcinoma having postoperative wound dehiscence

To evaluate and compare the wound healing outcome of Superoxidised solution and Calendula Officinalis flower extract used for local wound care in patients of oral squamous cell carcinoma having postoperative wound dehiscence: A randomized controlled trial.

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041194

Enrollment

Registered

2022-03-17

Start date

Unknown

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C030- Malignant neoplasm of upper gum Health Condition 2: C031- Malignant neoplasm of lower gum Health Condition 3: C039- Malignant neoplasm of gum, unspecified Health Condition 4: C000- Malignant neoplasm of external upper lip Health Condition 5: C001- Malignant neoplasm of external lower lip Health Condition 6: C002- Malignant neoplasm of external lip, unspecified Health Condition 7: C003- Malignant neoplasm of upper lip, inner aspect Health Condition 8: C004- Malignant neo

Interventions

Intervention1: Calendula officinalis flower extract: dose-1 ml if calendula mother tincture frequency-twice daily route of administration-topical application duration of therapy-20 days Control Interv

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patients who have undergone surgical intervention for management of oral squamous cell carcinoma(OSCC) with Neck dissection 2)Patients who have a wound dehiscence of less than equal to 2 cmÂ² post OSCC surgery 3)Patients requiring no surgical intervention for correction of wound dehiscence.

Exclusion criteria

Exclusion criteria: 1)Previous history of Radiotherapy & chemotherapy 2)Previous history of neck dissection 3)Recurrence of OSCC 4)Coagulation disorder 5)Patient unfit for surgery 6)Patients with known allergy to herbal medication

Design outcomes

Secondary

Measure	Time frame
Allergy to Calendula Officinalis flower extractTimepoint: On Day 1 of topical application	—

Primary

Measure	Time frame
1)Size of wound 2)Depth of wound 3)Edges of wound 4)Undermining 5)Necrotic tissue type 6)Necrotic tissue amount 7)Exudate type 8)Exudate amount in wound 9)Skin color of surrounding wound. 10)Peripheral tissue edema 11)Peripheral tissue Induration 12)Granulation tissue 13)EpithelizationTimepoint: WOund dehiscence assessment on day1,5,10,15,20 post wound dehiscence	—

Countries

India

Contacts

Public ContactRaj Kumar Chakraborty

Sharad Pawar dental College and hospital

drnitinbhola@gmail.com9970070607

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026