To study the efficacy of combination therapy(NPWT plus Topical oxygen therapy) over NPWT alone on large post traumatic wound healing

To study the effect of combination therapy(NPWT plus Topical oxygen) versus Negative pressure wound therapy (NPWT) alone on large post traumatic wounds : A pilot Randomized Control Trial

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041091

Enrollment

Registered

2022-03-15

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: T14-T14- Injury of unspecified body region

Interventions

Intervention1: Combination therapy: Negative pressure between -80 mm of Hg to -200 mm of Hg. Topical oxygen is given in the range of 5 - 30ml/Hr Dressing changed on every fourth day i,e., Day1, 5, 9 C

Eligibility

Inclusion criteria

Inclusion criteria: Large traumatic wounds requiring NPWT (decided by a clinician)

Exclusion criteria

Exclusion criteria: Pregnant females Patients with comorbidities like Hypertension, Diabetes, CKD, CLD, immunocompromised, etc. Patients with coagulopathy, heparin therapy Patients in whom NPWT cannot be applied due to site issues

Design outcomes

Primary

Measure	Time frame
Number of days of therapy required for wound bed preparation for closure or coverTimepoint: Day4, Day8, Day 12.	—

Secondary

Measure	Time frame
wound contraction rates wound health Duration of hospital stayTimepoint: After each dressing change.	—

Countries

India

Contacts

Public ContactChigurupati Veda Samhitha

JPNATC, AIIMS DELHI

sagar.sushma@gmail.com8500837961

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026