Health Condition 1: K746- Other and unspecified cirrhosis ofliver
Conditions
Interventions
Intervention1: Temporary porto caval shunt (TPCS): In Temporary porto caval shunt (TPCS) group, Hilar dissection( division of Hepatic artery, Bileduct) is followed by temporary portocaval shunt forma
Sponsors
Institute of Liver and Biliary Sciences
Eligibility
Inclusion criteria
Inclusion criteria: -All Adult LDLT Recipients at ILBS, New Delhi
Exclusion criteria
Exclusion criteria: Acute Liver Failure as an indication for transplant Pediatric transplants Presence of Yerdel grade III and grade IV Portal vein thrombosis Presence of significant portosystemic shunting (greater than 10mm) in pre operative period Patients who have undergone TIPS procedure. Hypercoagulable states like Budd-Chiari syndrome Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the hemodynamic parameters, Blood loss, Renal function, at fixed time points during perioperative period and duration of surgery between two groupsTimepoint: Time line for measurement for intra op haemodynamic parameters T0- At the beginning of the procedure T1- Before portocaval shunt formation T2- Just before Reperfusion of graft liver T3- 5 mins after Reperfusion of graft liver T4-Before closure of the abdomen Blood Loss- Measured at the end of Liver Transplantation procedure Post op Renal function- POD0 till patient is discharged Duration of surgery- From incision time to end of procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| Early allograft dysfunctionTimepoint: For 5 consecutive days after day 7;Endotoxin levelsTimepoint: Levels of Serum endotoxin levels in pre op and 12 hours after surgery;ICU and hospital stayTimepoint: POD0 till discharge;Incidence of Morbidity and sepsisTimepoint: POD0 till discharge;To compare tolerance to enteral feed between two groupsTimepoint: Tolerance to enteral feeding in the post op period is Post operative day patient tolerates NG feed | — |
Countries
India
Contacts
Public ContactDr Manoj Kumar YL
Institute of Liver and Biliary Sciences
Outcome results
None listed