To find the effective dose of ropivacaine for spinal anaesthesia in day care surgery

The 90% Effective Dose (ED 90) of 0.75% Intrathecal Ropivacaine for Day Care Surgery in Patients Undergoing Lower Abdominal, Inguinal and Urological Surgery- Estimation with the Biased Coin Up-and-Down Sequential Method

Status

Active, not recruiting

Phases

Phase 1

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/041059

Enrollment

Registered

2022-03-14

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intrathecal ropivacaine: The first subject is assigned a pre-determined dose of intrathecal ropivacaine. For subsequent subjects, dose will be determined using biased coin method. Inter

Eligibility

Inclusion criteria

Inclusion criteria: 1. Consenting patients scheduled to undergo day care surgery 2. Age 18-60 Years 3. Height: 160 cm â?? 175 cm 4. Male patients 5. Weight: 50-80 Kg 6. ASA 1 and 2

Exclusion criteria

Exclusion criteria: -Spinal abnormalities -Surgeries expected to exceed a duration of 2 hours -Infection at the site of spinal injection -Coagulopathies -Allergy to amide local anesthetics -Long standing diabetics

Design outcomes

Primary

Measure	Time frame
Effective dose (ED90) of intrathecal 0.75% isobaric ropivacaine for day care surgery using the biased coin designTimepoint: Intraoperatively, and postoperatively, until patient achieves discharge criteria	—

Secondary

Measure	Time frame
1. Time to achieve discharge criteria after successful block 2. Hemodynamic variations with different doses of 0.75% ropivacaine. 3. Onset and duration of sensory and motor block with different doses of 0.75% ropivacaine 4. Patient satisfaction score. 5. Surgeon satisfaction score. Timepoint: Intraoperatively, and postoperatively, until patient achieves discharge criteria	—

Countries

India

Contacts

Public ContactHarsha Binu

All India Institute of Medical Sciences, New Delhi

rashmiramachandran1@gmail.com9811422188

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026