Health Condition 1: C541- Malignant neoplasm of endometrium
Conditions
Interventions
Intervention1: vault brachytherapy: 5Gy HDR per fraction for 5 fractions to be treated daily for 5 consecutive days
Control Intervention1: Vault brachytherapy: 7Gy HDR per fraction for 3 fractions, on
Sponsors
Post Graduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age >18 years 2. ECOG 0-1 3. Histologically confirmed cases of Endometroid endometrial carcinoma
Exclusion criteria
Exclusion criteria: 1. Poor performance status 2. Serous or clear cell carcinoma endometrium, sarcoma or carcinosarcoma 3. Stage >1, stage 1a grade 1 4. Uncontrolled Comorbidities 5. No prior history of pelvic radiotherapy 6. Residual macroscopic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the outcome (local control) of vault brachytherapy schedules of 5 Gy x 5 fractions over a week and 7 Gy in 3# in intermediate group endometrial carcinoma. To compare the toxicities of different brachytherapy schedules in endometrial cancers. Timepoint: Base line, at 3 month first followup, 6 month, 9 month, 12 month, 24 month, 36 month, 48month | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare health related quality of life To evaluate Overall survival and failure free survival Timepoint: Assess quality of life: at 3 month, 6 month, 9 month, 12 month, 2 years, 3 years Assess the overall survival till death and failure free survival till disease recures | — |
Countries
India
Contacts
Public ContactSrinivasa G Y
Post Graduate Institute Of Medical Education and Research
Outcome results
None listed