Health Condition 1: J309- Allergic rhinitis, unspecified
Conditions
Interventions
Intervention1: Nasal cortico-steroid spray, anti-histamines: Fluticasone furuate nasal cortico-steroid spray 2 puffs twice a day, oral levocetrizine 5 mg once a day for 3 months
Control Intervention1:
Sponsors
Shuchita Singh Pachaury
Eligibility
Inclusion criteria
Inclusion criteria: We would recruit the subjects from among the patients attending the ENT OPD for vitamin D deficient allergic rhinitis not taking any therapy for last 3 weeks - Any subject who gives consent to be a part of the study
Exclusion criteria
Exclusion criteria: History of any major systemic or local medical illnesses, like diabetes mellitus, hypertension, tuberculosis, liver diseases, inflammatory conditions or any auto-immune disorder, or local pathologies like nasal polyp or nasal mass - Those who do not give the consent for participation - History of hypersensitivity to steroids - Pregnant woman and lactating mothers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. To analyze the expressions of nasal epithelial brushing micro-RNAs (miR-126-5p, miR-19a-5p, miR-26a-5p, miR-221, miR-142-3p, miR-223, miR-133b, miR-181a, miR-193b, miR-375 and let-7) in patients of vitamin D deficient allergic rhinitis. 2. To correlate these specific nasal epithelial brushing miRNA levels with SNOT (Sino nasal outcome test) score and serum Vitamin D levels for disease severity both before and after 3 months of therapyTimepoint: After 3 months of therapy | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the levels of nasal epithelial brushing miRNAs before and after 3 months of treatmentTimepoint: Post 3 months therapy | — |
Countries
India
Contacts
Public ContactShuchita Singh Pachaury
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed