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Fatty acid metabolism and inflammation in gestational diabetes mellitus

Exploring the role of maternal fatty acids, placental fatty acid metabolism, and inflammation in determining infant health in gestational diabetes mellitus

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/03/040946
Enrollment
400
Registered
2022-03-09
Start date
Unknown
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

None listed

Sponsors

Department of Biotechnology Government of India
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Children born to already recruited 200 gestational diabetes mellitus (GDM) women and 200 non GDM women (subjects with normoglycemia).

Exclusion criteria

Exclusion criteria: Women who had a history of cardiovascular disease, seizure or liver disorder, congenital abnormality at the 18-22 weeks scan, women with bleeding disorders, HIV or HBsAg were excluded and not recruited.

Design outcomes

Primary

MeasureTime frame
Fatty acids in early pregnancy, placental fatty acid metabolism (fatty acid oxidation and transport) and placental fatty acid derived specialized proresolving mediators (resolvins, protectins, lipoxins) and their metabolites (17-hydroxy docosahexaenoic acid, 18-hydroxyeicosapentaenoic acid, 14- hydroxy docosahexaenoic acid) in women who develop gestational diabetes mellitus (GDM) and compare them with non GDM mothersTimepoint: 11-14 weeks of pregnancy and at delivery—

Secondary

MeasureTime frame
Association of fatty acid metabolites and inflammation with anthropometric measures, blood pressure, glucose and cognitive function of infants at 4 - 6 yrs of ageTimepoint: Children at 4 - 6 yrs of age—

Countries

India

Contacts

Public ContactDr Sanjay Gupte

Interactive Research School for Health Affairs (IRSHA), BVDU

sadhana.joshi@bharatividyapeeth.edu8007945167

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026