Efficacy of using antibiotic medication prior and post lower third molar surgery along with a pre-operative dose of anti-inflammatory drug on complications after performing third molar surgery

Efficacy of combination of perioperative antibiotics and pre-operative anti-inflammatory drug in reducing complications following lower third molar surgery â?? A single-center, single-blind, randomized control trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/040901

Enrollment

Registered

2022-03-08

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Drug intervention: Pre-procedure: Amoxicillin/Clavulanate(500/125)mg tablets x 2. Inj. Dexamethasone 8mg intravenously x 1. Post-extraction: Diclofenac Sodium 50mg tablets - SOS. Durat

Eligibility

Inclusion criteria

Inclusion criteria: 1. Lower third molars indicated for surgical extraction (Pedersen index: 3-5) 2. Healthy individuals (ASA Class 1 or 2)

Exclusion criteria

Exclusion criteria: 1. Age < 18 years 2. Pregnant/breast-feeding women 3. Allergy to study medication or related drugs 4. Consumption of antibiotics in the week before surgery 5. Teeth with signs of acute pericoronitis 6. Patients who cannot comply with follow-up schedule 7. Patients with history of gastritis, peptic ulcer, and under medication for the same

Design outcomes

Primary

Measure	Time frame
Presence of signs of infection and need for rescue analgesics post- surgery.Timepoint: Outcome variables will be measured on the first, third, and seventh day post-operatively	—

Secondary

Measure	Time frame
Improvement/worsening of pain, swelling, and trismusTimepoint: Outcome variables will be measured on the first, third, and seventh day post-operatively	—

Countries

India

Contacts

Public ContactRamya K Suryanarayan

Manipal Academy of Higher Education

srikanth.mds@manipal.edu

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026