margins after chemotherapy in surgery of oral cancer

PATHOLOGICAL MARGINS IN ORAL CANCERS AFTER NACT- A RANDOMISED CONTROL STUDY (MARNACT): - MarNact(margins after NACT)

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/03/040885

Enrollment

Registered

2022-03-07

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C069- Malignant neoplasm of mouth, unspecified Health Condition 2: C148- Malignant neoplasm of overlappingsites of lip, oral cavity and pharynx

Interventions

Intervention1: SURGERY OF ORAL CANCER: WIDE LOCAL EXCISION OF THE MALIGNANT ORAL CANCER WITH NECK DISSCETION AND RECONSTRUCTION Intervention2: SURGERY: Wide local excision of oral cancer with neck dis

Eligibility

Inclusion criteria

Inclusion criteria: STAGE: T4A, T4b 1.Age: 18 years of age and above 2.Site: oral cavity (8 subsites: mucosal lip, buccal mucosa, lower and upper alveolar ridge, RMT, floor of mouth, hard palate, anterior2/3 rd of tongue. 3.Operability: border line operable cases 4. Gc: ecog-0/1 5. Comorbidities: controlled HTN, controlled DM, systolic dysfunction less than or equal to grade2. 6.Prior treatment for cancer: nil

Exclusion criteria

Exclusion criteria: 1.Early stages of oral cancer (STAGE1,2,3) 2. Age less than 18 years 3. Gc-PS: more than or equal to 2 4.PRIOR TREATMENT FOR HEAD AND NECK CANCER IN LESS THAN 5 YEARS 5. Non responders to NACT clinically after 2nd cycle. 6. Comorbidities: uncontrolled HTN, uncontrolled DM, systolic dysfunction more than grade 2

Design outcomes

Primary

Measure	Time frame
Compare pathological margins in patients of oral cancer Who under go surgery after NACT Timepoint: 1month and 6months	—

Secondary

Measure	Time frame
Margin positivity rate T4aVST4b â?¢Short term recurrence T4aVST4bTimepoint: 6 MONTHS	—

Countries

India

Contacts

Public ContactGopi satya sai reddy Gontu

Dr. Bhubneshwar boorah cancer institute

akdas171@gmail.com9954139727

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026