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To compare stabilising effect on blood pressure and heart rate of esmolol bolus and esmolol infusion in CABG patients during laryngoscopy, endotracheal intubation and sternotomy under general anaesthesia.

A comparative study of bolus versus continuous infusion of esmolol on hemodynamic response to laryngoscopy,endotracheal intubation and sternotomy in coronary artery bypass graft surgery under general anaesthesia; A randomised double blind interventional study at S.M.S medical college and hospital, Jaipur during 2020-2021

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/03/040882
Enrollment
98
Registered
2022-03-07
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: injection esmolol 1.5mg per kg bolus dose.: inj.esmolol 1.5mg/kg bolus 2 mins before induction and infusion 20ml saline 10 mins before induction,in a CABG patient under general anaesthe

Sponsors

Sawai Man Singh Medical College and Hospitals
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: . Scheduled for CABG surgery 2. Either sex 3 . Age group 40-70yrs 4. Ejection fraction >40% 5. ASA Grade II & lll

Exclusion criteria

Exclusion criteria: 1. Patients not willing to participate in study 2. Uncooperative patients 3. Patients with history of drug allergy to beta blockers. 4. Patients with pre-existing, Asthma, Renal or Hepatic dysfunction. 5. First degree AV block. 6. Heart rate 7. Mallampati score more than 2 8. Patient contraindicated for beta blocker agents . 9. Pregnancy/Lactation

Design outcomes

Primary

MeasureTime frame
: To compare the effectiveness of mode of administration of i.v. injection of bolus esmolol and i.v infusion of esmolol to attenuate the haemodynamic response to laryngoscopy, endotracheal intubation and sternotomy in the form of - ï?¬ Heart rate ï?¬ Systolic blood pressure ï?¬ Diastolic blood pressure ï?¬ Mean arterial blood pressure ï?¬ Spo2 Timepoint: till sternotomyor till 20th minute of induction of general anaesthesia.—

Secondary

MeasureTime frame
To identify which mode of esmolol have least side effects and complications.Timepoint: Till sternotomy or 20th minute of induction—

Countries

India

Contacts

Public ContactDr Swati

Sawai Man Singh Medical College and Attached Hospitals

adhokshajj@gmail.com9414373226

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026