Health Condition 1: G988- Other disorders of nervous system Health Condition 2: G998- Other specified disorders of nervous system in diseases classified elsewhere
Conditions
Interventions
Intervention1: Dexmedetomidine: Dexmedetomidine administration before intubation at 1ug/kg over 10 mins and then on maintainable dose at 0.2-0.7ug/kg/hr via iv route. Maintainance dose stopped 10 min
Sponsors
DR Ram Manohar Lohia Institute Of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patients ASA class 1 and 2 2. Age >18 and 3. patient should receive dexmedetomidine (0.3-0.5 mcg /kg/ hr)
Exclusion criteria
Exclusion criteria: 1. Patient refusal to give consent. 2. Patient ASA class 3 and 4. 3. Age 60 yrs. 4. Patients with preoperative heart rate 5. Presence of any heart block of any degree. 6. Any known allergy to dexmedetomidine or other alpha agonists.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| : Comparative evaluation of the estimated Cerebral perfusion pressure (eCPP) from baseline to after loading dose of dexmedtomidine, after intubation and at the end of procedure.Timepoint: at baseline ,after loading dose of dexmedtomidine, after intubation and at the end of procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| Evaluation of Mean flow velocity (mFV) ,Pulsatility index (PI), Cerebral vascular resistant index (CVRi) and dynamic cererbral autoregulation from baseline to after loading dose of dexmedetomidine, after intubation and at the end of procedure.Timepoint: At the baseline , after administration of loading dose of dexmedetomidine, after intubation and at the end of procedure. | — |
Countries
India
Contacts
Public ContactJYOTI VERMA
RML INSTITUTE OF MEDICAL SCIENCE LUCKNOW
Outcome results
None listed