Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: intranasal spray of Tapentadol Group N: 2 puffs of nasal Tapentadol
15 mins before induction of anaesthesia
Control Intervention1: Tab Tapentadol 100mg 1 tablet per oral:Group T: Tab T
Sponsors
RKMSP VIMS
Eligibility
Inclusion criteria
Inclusion criteria: 1.ASA Grade I and II 2.Elective laparoscopic cholecystectomies 3.Operations performed under general anaesthesia 4.Less than or equal to 120 mins duration
Exclusion criteria
Exclusion criteria: Body weight 60 kg Known hypersensitivity to any of the test drugs With coagulopathies or on anticoagulant On MAO inhibitors or SSRI sTaking opioid drugs or analgesic drugs Pregnant or lactating mothers Patient having atrophic rhinitis or nasal pathology R
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters including HR, SBP, DBP, MAP, RPP and any adverse effect will be recorded 1 min after intubation . Then the parameters will be recorded at intervals till the end of surgery. In the post operative period parameters will be recorded at 5mins, 120 mins, 240 mins after extubation. Timepoint: Hemodynamic parameters including HR, SBP, DBP, MAP, RPP and any adverse effect will be recorded 1 min after intubation . Then the parameters will be recorded at 15mins,30mins,45mins,60mins,75mins,90mins,105mins,120mins,till the end of surgery. In the post operative period parameters will be recorded at 5mins, 120 mins, 240 mins after extubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| VAS score ( Scale 1-10) will be recorded in the post operative period at intervals.Timepoint: VAS score ( Scale 1-10) will be recorded in the post operative period at 5mins, 120 mins, 240 mins after extubation. | — |
Countries
India
Contacts
Public ContactDr Keya Chakraborty
RKMSP & VIMS Kolkata
Outcome results
None listed