Health Condition 1: K51- Ulcerative colitis
Conditions
Interventions
Intervention1: PEN Group: Patients will be given partial enteral nutrition of which 50% will be provided by a semi elemental formula feed and rest 50% using an anti-inflammatory diet for a period of
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: Those with acute severe ulcerative colitis diagnosed on the basis of Modified Truelove and Wittââ?¬•s criteria
Exclusion criteria
Exclusion criteria: Patients who deny consent Age ââ?°Â¤ 18years Pregnant and lactating women Presence of toxic megacolon as defined by transverse colon diameter more than 5.5cm on abdominal X-ray Infective exacerbation Presence of dysplasia or any indication for surgery Patients who are deemed to require surgery in next 48 hours Diagnosis is uncertain like Crohnââ?¬•s or indeterminate colitis Disease extent: E1 disease (15cm or less) Very low BMI ( Very high risk of refeeding syndrome (prolonged fasting i.e > 3 days OR low energy diet i.e less than 50% of calorie requirement for > 7 days OR dyselectrolytemia in form of serum K of
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Need for second line therapy or colectomy during index admissionTimepoint: 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in C- reactive protein by day 7Timepoint: Day 7;Changes in fecal calprotectin by day 7Timepoint: 7 days;Changes in serum albumin by day 28 Timepoint: Day 28;Response at day 3 as defined by Oxford criteriaTimepoint: 3 days | — |
Countries
India
Contacts
Public ContactVishal Sharma
Department of Gastroenterology, Postgraduate Institute of Medical education and Research
Outcome results
None listed