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Micro-RNA 15a-5p dysregulation and its Target Gene in Oral cancer and normal tissue

Evaluating the expression of micro-RNA-15a-5p and YAP1 gene in oral squamous cell carcinoma in comparison with normal tissue. A cross-sectional study.

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2022/03/040790
Enrollment
44
Registered
2022-03-03
Start date
Unknown
Completion date
Unknown
Last updated
2023-06-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C068- Malignant neoplasm of overlappingsites of other and unspecified parts of mouth

Interventions

Control Intervention1: Normal tissues: â?¦ Patients diagnosed with epithelial tissue disorders and any other oral lesions. â?¦ Patients with no history of treated or untreated malignancies of any othe

Sponsors

DR S PADMAVATHI
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: GROUP A: INCLUSION: â?¦ Clinically and histologically diagnosed oral carcinoma patients. GROUP B: INCLUSION: Healthy individuals who undergo extraction prior to the commencement of orthodontic procedure without any periodontal diseases.

Exclusion criteria

Exclusion criteria: GROUP A: EXCLUSION: â?¦ Patients diagnosed with epithelial tissue disorders and any other oral lesions. â?¦ Patients with no history of treated or untreated malignancies of any other system. â?¦ The patient is not willing to participate. â?¦ Patients diagnosed with any pre-malignant lesions. GROUP B: EXCLUSION: â?¦ Patients are not willing to participate. â?¦ Patients diagnosed with other pre-malignant lesions. â?¦ Clinically diagnosed carcinoma patients.

Design outcomes

Primary

MeasureTime frame
Dysregulation of miRNA-15a-5p in OSCC compared to normal tissues and the relation with YAP1 gene. Timepoint: MONTHS0-67-1213-16 NO.OF CASES 10 20 14

Secondary

MeasureTime frame
Dysregulation of miRNA-15a-5p in OSCC compared to normal tissues and the relation with YAP1 gene. Timepoint: MONTHS 0-6 7-12 13-16 NO.OF CASES 10 20 14

Countries

India

Contacts

Public ContactPADMAVATHI S

SRM DENTAL COLLEGE

kannan_mds@yahoo.co.in09444298733

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026