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Effect of Anesthesia technique on anti tumor immunity as seen by TNF-B levels in adult patients undergoing surgery for oral cancer

Effect of intravenous Lignocaine and Dexmedetomidine infusion based anaesthetic technique on anti-tumor immunity as assessed by transforming growth factor-ß levels in adult patients undergoing surgery for Oral cancer: a prospective randomized study.

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/03/040751
Enrollment
90
Registered
2022-03-02
Start date
Unknown
Completion date
Unknown
Last updated
2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C10- Malignant neoplasm of oropharynx

Interventions

Intervention1: 2% LIGNOCAINE intravenous infusion based anesthesia: One arm of the trial patients will receive 2% LIGNOCAINE intravenous infusion in intraoperative and 24 hrs. post operative period In

Sponsors

Department of OncoAnesthesia and Palliative Medicine DR BRAIRCH AIIMS New Delhi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Patients undergoing surgery for Oral cancer 2) American Society of Anesthesiologists classification of Physical Health GRADE I, II, III.

Exclusion criteria

Exclusion criteria: 1.Patient refusal. 2.Allergy to any of the study drugs. 3.Chronic kidney and liver disease. 4.Blood transfusion in perioperative period.(30 days prior to surgery and Up to 24 hrs postoperative period) 5.Atrioventricular conduction disorders.(Either with pacemaker or on antiarrhythmics) 6.Heart failure on treatment with beta blockers. 7.Patients with chronic pain preoperatively already receiving Opioids.

Design outcomes

Primary

MeasureTime frame
To detect the difference in the Post-operative Serum TGF-ß levels in patients receiving lignocaine infusion and dexmedetomidine infusion based anaesthesia in patients of Oral Cancer undergoing surgery.Timepoint: 24 hrs after surgery in postoperative period—

Secondary

MeasureTime frame
To compare incidence of peri-operative complications (pruritus, nausea, vomiting, bradycardia, hypotension) among the study groups.Timepoint: 24 hrs after surgery in postoperative period;To compare the total opioid consumption in perioperative period among the study groups.Timepoint: 24 hrs after surgery in postoperative period;To detect the difference in perioperative systemic inflammation and anti-tumour immunity: change between preoperative and postoperative T-helper cell profile, IL-6, Neutrophil Lymphocyte ratio (NLR), Platelet Lymphocyte ratio (PLR), Monocyte Lymphocyte Ratio (MLR) and modified Glasgow Prognostic Score (m GPS).Timepoint: 24 hrs after surgery in postoperative period—

Countries

India

Contacts

Public ContactTanmay Mathur

All India Institute of Medical Sciences

sachidadr@yahoo.co.in9757010563

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026