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Histologic response of dental pulp to different pulp capping materials

Histological evaluation of dental pulp response to Biodentine, enamel matrix derivative (Emdogain) and mineral trioxide aggregate (MTA) as direct pulp capping agents

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2022/02/040683
Enrollment
78
Registered
2022-02-28
Start date
Unknown
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K026- Dental caries on smooth surface

Interventions

Intervention1: Biodentine: pulp capping was done with Biodentine(Septodont, Saint-Maur-des-Fosses, France) Duration: 6months Intervention2: Emdogain: Pulp capping was done with emdogain ((BIORA AB, M

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Healthy patients in the age group of 14-25 2) Fully erupted permanent teeth (mandibular and maxillary planned for extraction due to periodontal involvement/ indicated for surgical extraction) 3) Minimum of 3 premolar teeth with closed apices scheduled for extraction for orthodontic treatment 4) Cases with vital mature teeth with symptomatic exposure of vital pulp tissue by caries or trauma and without radiographic evidence of periapical lesion

Exclusion criteria

Exclusion criteria: 1) Pulpal involvement/ presence of periapical radiolucency 2) Spontaneous and nocturnal toothache 3) Tooth mobility 4) Developmental defects 5) No response to pulp sensibility tests 6) Uncontrollable hemorrhage at the time of exposure 7) Patients unwilling to participate 8) Immunocompromised patients

Design outcomes

Primary

MeasureTime frame
Inflammatory cell response Dentin bridge formationTimepoint: 6months

Secondary

MeasureTime frame
Dentin bridge formationTimepoint: 6Months

Countries

India

Contacts

Public ContactDr T Premlata Devi

RIMS, Imphal

tpremlatadevi@yahoo.com9856082362

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026