Health Condition 1: D024- Carcinoma in situ of respiratory system, unspecified
Conditions
Interventions
Intervention1: Fractionated Stereotactic Radiotherapy: it gives radiotherapy from many different angles around the body . The beam meet at the tumor. it delivers high dose to tumor and much lower dose
Sponsors
AIIMS NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: 1. NSCLC (pathologic confirmation) with 1-4 brain metastasis all smaller than 3 cm in diameter. 2. Adult patients (>=18 years of age), 3. Eastern Cooperative Oncology Group[ECOG] performance status 4. Graded Prognostic Assessment (GPA) >=1.5 5. All standard tumour-staging procedures necessary to define baseline extracranial disease status 6. Systemic treatment as per institute guidelines and physician discretion.
Exclusion criteria
Exclusion criteria: 1. Pregnant women 2. Inability to complete a magnetic resonance imaging scan with contrast 3. Prior resection of cerebral metastasis 4. Chemotherapy within 7 days of preregistration or planned chemotherapy during the radiotherapy 5. Prior cranial radiotherapy 6. Pacemaker or other MRI non-compatible metal in the body 7. Known allergy to gadolinium 8. Leptomeningeal metastases 9. Lesion located within 5 mm of the optic chiasm or within the brainstem 10. Inability to undergo contrast enhanced computed tomography 11. Inability to give consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intracranial tumour control rates. Neuro cognitive decline .Timepoint: Intracranial tumor control rate at 3 months Neuro congnitive assessment at 4 weeks. | — |
Secondary
| Measure | Time frame |
|---|---|
| â?¢ Cognitive outcomes for individual cognitive assessments: Defined as a decline of greater than 1 SD from baseline on cognitive tests (all tests are standardized based on published norms and transformed so that higher values represent improved cognition) at the 3-month post treatment evaluation.Timepoint: 3 monnths | — |
Countries
India
Contacts
Public ContactSushmita Pathy
ALL INDIA INSTITUTE OF MEDICAL SCIENCES, NEW DELHI
Outcome results
None listed