Assessment of the effects of anaesthetic agents on cerebral vasculature.

To Compare the effects of Propofol and Sevoflurane on diseased cerebral vasculature assessed by digital substraction angiography:A Prospective Randomized Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2022/02/040527

Enrollment

Registered

2022-02-23

Start date

Unknown

Completion date

Unknown

Last updated

2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I679- Cerebrovascular disease, unspecified

Interventions

Intervention1: Sevoflurane: Patient will be asked to inhale sevoflurane given initially at 5% by asking the patient to take normal tidal volume breaths till the loss of eye lash reflex to achieve a st

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18years to 75 years Patients scheduled for therapeutic endovascular neuro-interventions 1. Patients with ruptured aneurysm undergoing endovascular coiling/ Flow diversion 2. Patients with unruptured aneurysm undergoing endovascular interventions 3. Patients with intracranial AVM undergoing endovascular embolisation

Exclusion criteria

Exclusion criteria: 1.Hemodynamically unstable patients 2.Intubated Patients 3.Patients having derranged Renal Parameters 4.Patients diagnosed to be having vasculitis 5.Patients diagnosed to be having cerebral vasospasm in preprocedural angiography 6.Patients diagnosed to be having hydrocephalus 7.Patients having abnormal coagulation parameters 8.Patients having Hemoglobin < 10gm/dl or Hematocrit < 30%

Design outcomes

Primary

Measure	Time frame
To compare the effects directly on the luminal diameter of cerebral vessels on the diseased side between propofol and sevofluraneTimepoint: 1. Pre-Induction of anaesthesia 2. 1 hour post-induction of anaesthesia 3. Post Completion of the Neuro-Endovascular Procedure	—

Secondary

Measure	Time frame
1. To compare the changes on cerebral blood flow indirectly by measuring cerebral transit time (CTT) between propofol and sevoflurane anaesthesia 2.To compare the effect on pro-inflammatory biomarker Neuron Specific Enolase (NSE) between propofol and sevoflurane anaesthesia Timepoint: 1.Pre-Induction of anaesthesia 2. 1 hour post-induction of anaesthesia 3. Post completion of neuroendovascular procedure 4. NSE estimation prior to procedure and 24 hours post procedure	—

Measure

Time frame

1. To compare the changes on cerebral blood flow indirectly by measuring cerebral transit time (CTT) between propofol and sevoflurane anaesthesia 2.To compare the effect on pro-inflammatory biomarker Neuron Specific Enolase (NSE) between propofol and sevoflurane anaesthesia Timepoint: 1.Pre-Induction of anaesthesia 2. 1 hour post-induction of anaesthesia 3. Post completion of neuroendovascular procedure 4. NSE estimation prior to procedure and 24 hours post procedure

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Countries

India

Contacts

Public ContactDR AUROBINDA KANUNGO

Post Graduate Institute of Medical Education and Research

nidhibp@Gmail.com7087009525

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026