Health Condition 1: G978- Other intraoperative and postprocedural complications and disorders of nervous system
Conditions
Interventions
Intervention1: collodis - hydroxyethyl starch is given to patients: Hydroxyethyl starch has been used as maintenance intravenous fluids along with crystalloid fluids
Control Intervention1: coagulation
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: • Patients undergoing Craniectomy for Brain pathologies • Age between 18 to 65 years • ASA I and II patients
Exclusion criteria
Exclusion criteria: 1. Patient refusal for consent 2. Extremes of age ( 65 years) 3. Pregnancy 4. Patients with known bleeding disorders/coagulopathy (Platelets 5. Patients on antiplatelets and anticoagulants 6. Patients with uncontrolled systemic disease (DM, HTN, CKD, Liver failure, CAD) 7. Chronic NSAIDS within recent 2 weeks prior to surgery 8. Chronic alcohol or drug abuse 9. Massive blood loss
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in coagulation parameters from baseline and at the end of surgery using Sonoclot in both the groupsTimepoint: baseline to end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Hemodynamic stability intraoperatively 2. Brain relaxation score (BRS) at opening and the end of surgery 3. Total blood loss 4. Intraoperative total fluid volume, Blood and blood products 5. Serum lactate levels/ Serum electrolytes 6. Renal functions 24 hours and 48 hours after surgery (Serum Cystatin-C levels and AKIN criteria) 7. Outcome at discharge by Modified Rankin Scale (MRS) Timepoint: 1. Hemodynamic stability - Intraoperative period 2. Brain relaxation score - at the opening of dura and closure of the dura 3. total blood loss - intraoperative period 4. Intraoperative total fluid volume, Blood and blood products - intraoperative period 5. Serum lactate levels/ Serum electrolytes - baseline, at the start of blood loss, at maximum allowable blood loss and at the end of surgery 6. Renal functions at 24 hours and 48 hours after surgery 7. Outcome by MRS - at discharge | — |
Countries
India
Contacts
Public ContactDr Kiran Jangra
PGIMER
Outcome results
None listed