Health Condition 1: J328- Other chronic sinusitis
Conditions
Interventions
Intervention1: NasoBiome - Composition of the nasal spray: mixture of prebiotics and postbiotics in normal saline. The composition comprises Zymosan A, Laminarin, Cellulose, Lactose N fucopentose, Cel
Sponsors
AIIMS Bhubaneswar
Government of Odisha Science and Technology Department
Eligibility
Inclusion criteria
Inclusion criteria: Adults (more than 18 years); Diagnosis of CRS based on American Academy of Otolaryngology-Head Neck Surgery guidelines, refractory CRS, Atrophic Rhinitis based on clinical examination
Exclusion criteria
Exclusion criteria: Pregnancy, comorbidities that preclude travel for follow up, declining to be included in the study, a SNOT22 score of less than 10, LM score of less than 4 in cases of CRS.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1. Microbiome profile of patients with chronic inflammatory diseases of the nose and PNS 2. Improved quality of life of patients with chronic inflammation of the nose and PNS (in CRS and Atrophic Rhinitis)Timepoint: 3 years | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Normal nasal microbiome profile across age and gender 2. The CT scan picture of the patients with the disease and following intervention 3. The histopathological changes following intervention in Chronic inflammatory diseases 4. To assess the change in the microbiome in these patients following intervention Timepoint: 3 years | — |
Countries
India
Contacts
Public ContactSAURAV SARKAR
All India Institute of Medical Sciences, Bhubaneswar
Outcome results
None listed