Health Condition 1: A419- Sepsis, unspecified organism
Conditions
Interventions
None listed
Sponsors
PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: Children aged between 01 year and 12 years who are admitted to PICU with sepsis
Exclusion criteria
Exclusion criteria: 1. Children less than one year of age 2. Children with obesity 3. Any clinical/abdominal condition obscuring visualization of kidneys by USG 4. Children with known Chronic Kidney Disease (CKD) 5. Children with CAKUT (Congenital anomalies of kidney and urinary tract) 6. Children with Chronic Systemic Hypertension
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Prognostic accuracy of Renal Resistive Index at admission to predict the development of acute kidney injury in critically ill children with sepsisTimepoint: Renal Resistive Index will be measured within 12 hours after admission to PICU. Urinary NGAL level will be measured within 12 hours of PICU admission. Renal function tests and Serum electrolytes are measured at admission and daily for initial 5 days | — |
Secondary
| Measure | Time frame |
|---|---|
| To determine the association between RRI and 1. Severity of AKI 2. Urinary NGAL at admission 3. Cumulative vasopressor dose 4. Fluid balance Timepoint: To determine the association between RRI and 1. Severity of AKI during initial 5 days of PICU admission 2. Urinary NGAL at admission 3. Cumulative vasopressor dose during initial 5 days of PICU admission 4. Fluid balance during initial 5 days of PICU admission | — |
Countries
India
Contacts
Public ContactMuthuvel R
PGIMER
Outcome results
None listed